Nitric oxide inactivates xanthine dehydrogenase and xanthine oxidase in interferon-gamma-stimulated macrophages.
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Summary
Upon stimulation with IFN-gamma, inducible nitric oxide in macrophages leads to post-transcriptional inhibition of XDH/XO, possibly minimizing the potential for tissue injury from XO released from macrophage into the inflammatory milieu.
- Type
- dissertation
- Published
- 1994-11-01
- Cited by
- 40
- References
- 34
- OpenAlex
- https://openalex.org/W7524568
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7218732
Keywords
Humanities, Political science, Art
References
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- Nitric oxide: an endogenous modulator of leukocyte adhesion.
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- A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues.
- Effect of endotoxin-induced cell injury on 70-kD heat shock proteins in bovine lung endothelial cells.
- Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors
Cited by
- REGULATION OF THE HUMAN XANTHINE OXIDOREDUCTASE GENE
- Tryptophan-catabolising enzymes in animal models
- Implicación de las especies reactivas del oxígeno en el síndrome de isquemia y reperfusión provocado por medios farmacológicos en el intestino delgado de rata
- Xanthine Oxidase Injurious Response in Acute Joint Injury
- Reperfusion injury and reactive oxygen species: The evolution of a concept
- Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene.
- Effects of cis‐resveratrol on inflammatory murine macrophages: antioxidant activity and down‐regulation of inflammatory genes
- Xanthine oxidase activity is not increased in the colonic mucosa of ulcerative colitis
- Determination of xanthine oxidoreductase forms: influence of reaction conditions.
- Protection of Reduced‐Size Liver for Transplantation
- Oxidative metabolism in rat hepatocytes and mitochondria during sepsis.
- Induction of nitric oxide and nitric oxide synthase mRNA by silica and lipopolysaccharide in PMA‐primed THP‐1 cells
- Enhanced expression and activity of xanthine oxidoreductase in the failing heart.
- Antioxidant activity and inhibitory effects of hydralazine on inducible NOS/COX-2 gene and protein expression in rat peritoneal macrophages.
- Inhibition of Xanthine Oxidase and Xanthine Dehydrogenase by Nitric Oxide
- Lung injury and oxidoreductases.
- Suicide inactivation of xanthine oxidoreductase during reduction of inorganic nitrite to nitric oxide.
- Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary disease's airways.
- Differential regulation of xanthine and NAD(P)H oxidase by hypoxia in human umbilical vein endothelial cells. Role of nitric oxide and adenosine.
- Regulation of oxidant production in acute lung injury.
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