In vivo induction of apoptosis in human lymphocytes by therapeutic fractionated total body irradiation.
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Summary
It is confirmed that ionizing radiations induce apoptosis in vivo in human lymphocytes and that the commitment to apoptosis can be determined after low doses (2 Gy) of therapeutic whole body irradiation, and the results suggest that susceptibility to apoptotic induction by ionized radiations could be related to previous therapy by cytotoxic drugs and possibly to the type of haematological malignancy.
- Type
- article
- Published
- 1995-09-01
- Cited by
- 42
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W7496700
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22833988
Keywords
Oscillograph, Scale (ratio), Geology, Physics, Optics
References
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- Apoptosis: The Molecular Basis of Cell Death
- Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.
- Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.
- Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line.
- Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.
- Cell Death Mechanisms and the Immune System
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.
- Monoclonal antibody-mediated tumor regression by induction of apoptosis.
- p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.
- Activation of Epstein–Barr virus latent genes protects human B cells from death by apoptosis
- Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli
- Drug-target interactions: only the first step in the commitment to a programmed cell death?
- bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship.
- Radiation-induced interphase death of rat thymocytes is internally programmed (apoptosis).
- Activation of polyubiquitin gene expression during developmentally programmed cell death.
- Receptor-stimulated death pathway is opened by antigen in mature T cells.
- Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
- Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
- Effects of cycloheximide and actinomycin D on radiation-induced apoptotic cell death in the developing mouse cerebellum.
Cited by
- The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis.
- Low dose palliative radiotherapy for splenomegaly in hematologic disorders
- Micronuclei in cytokinesis-blocked lymphocytes may predict patient response to radiotherapy.
- Age dependence of T-lymphocyte apoptosis induced by high-energy proton exposure
- HOVON 47/EORTC 20013: chlorambucil vs 2×2 Gy involved field radiotherapy in stage III/IV previously untreated follicular lymphoma patients
- Clinical indications and biological mechanisms of splenic irradiation in chronic leukaemias and myeloproliferative disorders.
- Splenic irradiation in the management of Waldenstrom macroglobulinemia
- Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells.
- Radiation-induced apoptosis.
- Lack of correlation between apoptosis and DNA single-strand breaks in X-irradiated human peripheral blood mononuclear cells in the course of ageing.
- Low Dose Total Body Irradiation for Relapsed Low Grade Non-Hodgkin's Lymphoma: Experience of National Cancer Institute, Cairo
- Iodine-131 treatment and chromosomal damage: in vivo dose-effect relationship
- Increased sensitivity of CLL‐derived lymphocytes to apoptotic death activation by the proteasome‐specific inhibitor lactacystin
- Evaluation of the effect of 90Sr beta-radiation on human blood cells by chromosome aberration and single cell gel electrophoresis (comet assay) analysis.
- In vitro radiation-induced apoptosis and early response to low-dose radiotherapy in non-Hodgkin's lymphomas.
- Ubiquitin-Proteasome System and Increased Sensitivity of B-CLL Lymphocytes to Apoptotic Death Activation
- Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment
- In vivo amifostine (WR-2721) prevents chemotherapy-induced apoptosis of peripheral blood lymphocytes from cancer patients.
- The role of low-dose total body irradiation in treatment of non-Hodgkin's lymphoma: a new look at an old method.
- APOPTOSIS INDUCED BY γ IRRADIATION IN PERIPHERAL BLOOD MONONUCLEAR CELLS IS NOT MEDIATED BY CYTOCHROME‐C RELEASE AND ONLY PARTIALLY INVOLVES CASPASE‐3‐LIKE PROTEASES
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