Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications.
Explore this paper's citation graph
Summary
Aldose reductase inhibitors firmly link defects in myo-inositol metabolism to activation of the polyol pathway in diabetes; the resulting "sorbitol-myo- inositol hypothesis" has been extended from its application to the lenses and peripheral nerves to most of the tissues involved with diabetic complications.
- Type
- review
- Published
- 1987-03-05
- Cited by
- 974
- References
- 54
- OpenAlex
- https://openalex.org/W1996424575
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28700386
Keywords
Polyol pathway, Aldose reductase, Medicine, Sorbitol, Diabetes mellitus
References
- Aldose reductase inhibition improves nerve conduction velocity in diabetic patients.
- The formation of inositol 1,2-cyclic phosphate on agonist stimulation of phosphoinositide breakdown in mouse pancreatic minilobules. Evidence for direct phosphodiesteratic cleavage of phosphatidylinositol.
- Altered retinal metabolism in diabetes. I. Microanalysis of lipid, glucose, sorbitol, and myo-inositol in the choroid and in the individual layers of the rabbit retina.
- The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase.
- Altered retinal metabolism in diabetes. II. Measurement of sodium-potassium ATPase and total sodium and potassium in individual retinal layers.
- Transport of myo-inositol into endoneurial preparations of sciatic nerve from normal and streptozotocin-diabetic rats.
- Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor.
- Effects of Acute Experimental Diabetes on Composite Energy Metabolism in Peripheral Nerve Axons and Schwann Cells
- The sorbitol pathway and the complications of diabetes.
- Diabetic polyneuropathy: the importance of insulin deficiency, hyperglycemia and alterations in myoinositol metabolism in its pathogenesis.
- CAN THE BB‐RAT HELP TO UNRAVEL DIABETIC NEUROPATHY?
- Sorbitol, inositol and nerve conduction in diabetes.
- Binding of an aldose reductase inhibitor to renal glomeruli.
- Oral supplementation of myoinositol: effects on peripheral nerve function in human diabetics and on the concentration in plasma, erythrocytes, urine and muscle tissue in human diabetics and normals *
- Active transport of myo-inositol and its relation to the sugar transport system in hamster small intestine.
- Retinopathy in Young-onset Diabetic Patients
- NIH conference. Aldose reductase and complications of diabetes.
- Dietary myo-inositol intake and peripheral nerve function in diabetic neuropathy.
- Significance of tissue myo-inositol concentrations in metabolic regulation in nerve.
- Sex Steroid Dependency of Diabetes-induced Changes in Polyol Metabolism, Vascular Permeability, and Collagen Cross-Linking
Cited by
- A myo-inositol pool utilized for phosphatidylinositol synthesis is depleted in sciatic nerve from rats with streptozotocin-induced diabetes.
- The effects of aldose reductase inhibitors in diabetic nephropathy.
- The lens in diabetes
- Free radicals in diabetic endothelial cell dysfunction.
- Decrease of nerve Na+,K(+)-ATPase activity in the pathogenesis of human diabetic neuropathy.
- Changes in the Redox State in the Retina and Brain During the Onset of Diabetes in Rats
- Polymorphisms of the aldose reductase gene and susceptibility to retinopathy in type 1 diabetes mellitus.
- Protective effects of bendazac lysine on early experimental diabetic nephropathy in rats
- Fibrates inhibit aldose reductase activity in the forward and reverse reactions.
- Diabetic nephropathy: where hemodynamics meets metabolism.
- Oxidative Stress in Diabetic Nephropathy
- Acetyl-L-Carnitine in Diabetic Polyneuropathy
- Mechanisms of diabetic neuropathy: axon dysfunction.
- The diabetic renal tubulointerstitium.
- Mechanisms of diabetic neuron damage: Molecular pathways.
- Hypertonic stress increases NaK ATPase, taurine, and myoinositol in human lens and retinal pigment epithelial cultures.
- The Efficacy of a Polyhydrated Ionogen Impregnated Dressing in the Treatment of Recalcitrant Diabetic Foot Ulcers: a Multi-centre Pilot Study
- Pathological Definition and Evaluation of Diabetic Neuropathy and Clinical Correlations
- Glucose modulation of aldose reductase mRNA expression and its activity in cultured calf pulmonary artery endothelial cells
- Diagnosis, classification, and treatment of diabetic peripheral neuropathy.
Related papers
- Polyol pathway in tissues of spontaneously diabetic Chinese hamsters (Cricetulus griseus) and the effect of an aldose reductase inhibitor, ONO-2235.
- Inhibitory effect of orally administered aldose reductase inhibitor SNK-860 on corneal polyol accumulation in galactose-fed rats
- Red Cell Sorbitol: An Indicator of Diabetic Control
- Effect of hyperglycemia on the polyol pathway in rat kidney during the perinatal period.
- Effects on rat renal osmolytes of extended treatment with an aldose reductase inhibitor.
- A novel zwitterionic inhibitor of aldose reductase interferes with polyol pathway in ex vivo and in vivo models of diabetic complications.
- The Effect of Oxidation on Sorbitol Pathway Kinetics
- Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes.