Angiotensin converting enzyme inhibitors improve contractile function of stunned myocardium by different mechanisms of action.
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Summary
It is found that the improved contractile function associated with enalaprilat treatment could largely be reversed by infusion of the potent cyclooxygenase inhibitor indomethacin, and the salutary effects of zofenopril and SQ 14,534 may be due in part to the antioxidant properties of the sulfhydryl moiety.
- Type
- article
- Published
- 1991-05-01
- Cited by
- 80
- References
- 52
- OpenAlex
- https://openalex.org/W1850188
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34894074
Keywords
Ampoule, Vapor pressure, Analytical Chemistry (journal), Chemistry, Hafnium
References
- Influence of Chronic Captopril Therapy on the Infarcted Left Ventricle of the Rat
- Accumulation of arachidonate in triacylglycerols and unesterified fatty acids during ischemia and reflow in the isolated rat heart. Correlation with the loss of contractile function and the development of calcium overload.
- Does captopril attenuate reperfusion‐induced myocardial dysfunction by scavenging free radicals?
- Concentration-dependent protection by captopril against ischemia-reperfusion injury in the isolated rat heart.
- Captopril-induced changes in prostaglandin production: relationship to vascular responses in normal man.
- Captopril: a free radical scavenger.
- Effect of Indomethacin on Collateral Blood Flow and Infarct Size in the Conscious Dog
- Captopril and enalaprilat do not scavenge the superoxide anion.
- Direct scavenging of free radicals by captopril, an angiotensin converting enzyme inhibitor.
- Renal prostaglandin E in the hypotensive mechanism of MK-421 in conscious rats.
- Antiarthritic drugs containing thiol groups scavenge hypochlorite and inhibit its formation by myeloperoxidase from human leukocytes. A therapeutic mechanism of these drugs in rheumatoid arthritis?
- A Bradykinin-Potentiating Factor (BPF) present in the Venom of Bothrops jararaca.
- Demonstration of increased myocardial lipid with postischemic dysfunction ("myocardial stunning") by proton nuclear magnetic resonance spectroscopy.
- Beneficial effects of milrinone and enalapril on long-term survival of rats with healed myocardial infarction.
- Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril.
- Prostaglandin redirection by thromboxane synthetase inhibition. Attenuation of myocardial stunning in canine heart.
- Protective effects of N-2-mercaptopropionyl glycine against myocardial reperfusion injury after neutrophil depletion in the dog: evidence for the role of intracellular-derived free radicals.
- Cardioprotective effects of enalapril in acute myocardial ischemia.
- Different relations between infarct size and occluded bed size in barbiturate-anesthetized versus conscious dogs.
- Protective effects of captopril and enalapril on myocardial ischemia and reperfusion damage of rat.
Cited by
- Drug Differences between ACE Inhibitors in Experimental Settings and Clinical Practice
- "Cardioprotection" by ACE-inhibitors in acute myocardial ischemia and infarction?
- Angiotensin II Receptor Antagonist EXP 3174 Reduces Infarct Size Comparable with Enalaprilat and Augments Preconditioning in the Pig Heart
- Local and neurohumoral control of coronary blood flow.
- Effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury: an overview.
- Comparison of the effects of ACE inhibition with those of Angiotensin II receptor antagonism on systolic and diastolic myocardial stunning in isolated rabbit heart
- Clinical Evidence that Nisoldipine Attenuates Stunning in Patients Post infarction
- Protective effects of enalapril in streptozotocin‐induced diabetic rat: studies of DNA damage, apoptosis and expression of CCN2 in the heart, kidney and liver
- Captopril improves retinal neovascularization via endothelin-1.
- Use of the ACE inhibitor zofenopril in the treatment of ischemic heart disease
- Infarct size limiting effect of apstatin alone and in combination with enalapril, lisinopril and ramipril in rats with experimental myocardial infarction.
- Long-term clinical experience with zofenopril
- Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options.
- Effects of captopril on ischaemia-reperfusion-induced arrhythmias in an in vivo rat model.
- Angiotensin-converting enzyme inhibition preserves endothelium-dependent coronary microvascular responses during short-term ischemia-reperfusion.
- Cardioprotection by ACE Inhibitors in Myocardial Ischaemia/Reperfusion
- Nicotine exacerbates postischemic contractile dysfunction of 'stunned' myocardium in the canine model. Possible role of free radicals.
- Cardiac production of angiotensin II and its pharmacologic inhibition: effects on the coronary circulation.
- Does Aspirin Attenuate the Effect of Angiotensin‐Converting Enzyme Inhibitors on Health Outcomes of Very Old Patients with Heart Failure?
- Antihypertensive and cardioprotective effects after angiotensin-converting enzyme inhibition: role of kinins.
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