Mutations in the "zinc fingers" or in the N-terminal region of the DNA binding domain of the human glucocorticosteroid receptor facilitate its salt-induced transformation, but do not modify hormone binding.
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Summary
Variations in the salt-sensitivity of the mutated 8S GR complexes as a function of the ligand suggest that the DBD may interact functionally (if not physically) with the LBD, and could be influenced by minor structural differences between agonist and antagonist-GR complexes.
- Type
- article
- Published
- 1992-03-01
- Cited by
- 4
- References
- 27
- OpenAlex
- https://openalex.org/W1562546
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32270948
Keywords
Humanities, Art
References
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- Identification of an epitope shared by the DNA-binding domain of glucocorticoid receptor and the B chain of insulin.
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- Effect of 1,10-Phenanthroline on DNA Binding by 1,25-(OH)2 Vitamin D Receptor
- The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor.
- Function/activity of specific amino acids in glucocorticoid receptors.
- Obituary: Étienne-Émile Baulieu (1927-2025).
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