Kinetics of binding, endocytosis, and recycling of EGF receptor mutants
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Summary
It is suggested that while EGF stimulates endocytosis for all receptors, high-affinity receptors bind and are internalized more quickly than low-Affinity receptors.
- Type
- article
- Published
- 1992-04-01
- Cited by
- 102
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W1556153
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16281682
Keywords
Political science
References
- A point mutation at the ATP‐binding site of the EGF‐receptor abolishes signal transduction.
- Effects of monensin on insulin interactions with isolated hepatocytes. Evidence for inhibition of receptor recycling and insulin degradation.
- Biological activities of EGF‐receptor mutants with individually altered autophosphorylation sites.
- Nonacylated human transferrin receptors are rapidly internalized and mediate iron uptake.
- Complete inhibition of transferrin recycling by monensin in K562 cells.
- Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis.
- Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.
- Rapid constitutive internalization and externalization of epidermal growth factor receptors in isolated rat hepatocytes. Monensin inhibits receptor externalization and reduces the capacity for continued endocytosis of epidermal growth factor.
- Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines.
- Ligand-induced desensitization of 125I-epidermal growth factor internalization.
- Three classes of epidermal growth factor receptors on HeLa cells.
- Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation.
- Effect of nonspecific forces and finite receptor number on rate constants of ligand--cell bound-receptor interactions.
- Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts.
- Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor
- Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor
- Signal transduction by receptors with tyrosine kinase activity.
- Monensin inhibits receptor-mediated endocytosis of asialoglycoproteins in rat hepatocytes.
- Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431.
- Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies.
Cited by
- Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain.
- Sorting motifs in receptor trafficking.
- A Mechanistic Tumor Penetration Model to Guide Antibody Drug Conjugate Design
- Regulation of Cell Signaling by Mig6 and Sprouty2 in Cancers With Egfr Mutations
- Coronary Microvascular Function and Beyond: The Crosstalk between Hormones, Cytokines, and Neurotransmitters
- Development of a Novel Test System for Screening Antagonists of ErbB Receptors in Breast Cancer
- Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
- Adenovirus E3 protein causes constitutively internalized epidermal growth factor receptors to accumulate in a prelysosomal compartment, resulting in enhanced degradation
- Raman spectroscopy as a detection and analysis tool for in vitro specific targeting of pancreatic cancer cells by EGF‐conjugated, single‐walled carbon nanotubes
- c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.
- Juxtacrine signaling is inherently noisy.
- Endocytosis and Lysosomal Targeting of Epidermal Growth Factor Receptors Are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domain (*)
- Growth factor receptor signalling: location, location, location.
- The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor*
- Phosphatidylinositol 3-Kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking (*)
- Cholesterol derivative of poly(ethylene glycol) inhibits clathrin-independent, but not clathrin-dependent endocytosis.
- Photo-immobilization of epidermal growth factor enhances its mitogenic effect by artificial juxtacrine signaling.
- Rabphilin-3A: A Multifunctional Regulator of Synaptic Vesicle Traffic
- Epidermal growth factor receptor dimerization monitored in live cells
- Spatial Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis
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