Tricyclic antidepressants and imidazolines as inhibitors of the alpha-adrenergic receptor mediated stimulation of phosphatidylinositol turnover in rat pineal gland.
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Summary
Both amitriptyline and oxymetazoline displace the dose-response curve for norepinephrine to the right in a parallel manner indicative of a competitive mode of inhibition by these two classes of drugs.
- Type
- article
- Published
- 1979-06-01
- Cited by
- 8
- References
- 22
- OpenAlex
- https://openalex.org/W1996084617
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29402733
Keywords
Stimulation, Phosphatidylinositol, Tricyclic, Endocrinology, Alpha (finance)
References
- Cyclitols and phosphoinositides
- Stimulation of 32 P i incorporation into phosphatidylinositol and phosphatidyglycerol by catecholamines and -adrenergic receptor blocking agents in rat pineal organ cultures.
- Alpha adrenergic and histaminergic effects of tolazoline-like imidazolines.
- Relationship of alpha-adrenergic receptors in rat pineal gland to drug-induced stimulation of phospholipid metabolism.
- Tricyclic antidepressants: therapeutic properties and affinity for alpha-noradrenergic receptor binding sites in the brain.
- Neurochemical and behavioral effects of clonidine and related imidazolines: interaction with alpha-adrenoceptors.
- Stimulation by local anesthetics of the metabolism of acidic phospholipids in the rat pineal gland.
- Inhibition of the uptake of tritiated catecholamines by antidepressant and related agents.
- Interaction of clonidine with pre- and post-synaptic adrenergic receptors of rat brain: effects on cyclic AMP-generating systems.
- Influence of tricyclic antidepressants on the adenylate cyclase-phosphodiesterase system in the rat cortex.
- Binding of alpha-and beta-adrenergic ligands to cerebral cortical membranes: effect of 6-hydroxydopamine treatment and relationship to the responsiveness of cyclic amp-generating systems in two rat strains.
- Regulation of noradrenaline release in the rat pineal through a negative feedback mechanism mediated by presynaptic alpha-adrenoceptors.
- Role of phospholipids in muscarinic binding by neural membranes.
- EFFECT OF BRAIN CORTEX PHOSPHOLIPIDS ON ADENYLATE‐CYCLASE ACTIVITY OF MOUSE BRAIN
- DEVELOPMENTAL AND REGIONAL VARIATIONS IN NEUROTRANSMITTER‐SENSITIVE ADENYLATE CYCLASE SYSTEMS IN CELL‐FREE PREPARATIONS FROM RAT BRAIN
- Cardiovascular effects of amitriptyline, nortriptyline, protriptyline and doxepin in conscious rabbits.
- Inositol phospholipids and cell surface receptor function.
- Solubilization, stabilization, and partial purification of brain adenylate cyclase from rat.
- A simple method for the isolation and purification of total lipides from animal tissues.
- Stimulus-response coupling at alpha-adrenergic receptors.
Cited by
- Changes in brain polyphosphoinositide metabolism induced by cationic amphiphilic drugs in vitro.
- Alterations of Phospholipid Metabolism in Rat Cerebral Cortex Mince Induced by Cationic Amphiphilic Drugs
- Differential Effects of Fluoronorepinephrines on Phosphatidylinositol Turnover in Rat Pinealocytes
- Differential release of serotonin and histamine from mast cells
- Antidepressant drugs and ethanol: Behavioral and pharmacokinetic interactions in mice
- Synthesis, stereochemistry, and isomeric transformations of cis- and trans-1,2-dimethyl-4-aryl-5-aroyl-2-imidazolines
- The Pharmacology of Melatonin
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