Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity.
Explore this paper's citation graph
Summary
Prolotherapy injection with 10% dextrose resulted in clinically and statistically significant improvements in knee osteoarthritis.
- Type
- article
- Published
- 2000-03-01
- Cited by
- 222
- References
- 82
- OpenAlex
- https://openalex.org/W12687
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28808543
Keywords
Medicine, Prolotherapy, Osteoarthritis, Visual analogue scale, Anterior cruciate ligament
References
- Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation.
- The evaluation of pain in patients with knee osteoarthritis: the knee pain scale.
- Functional evaluation of normal and pathologic knees during gait.
- Criteria for classification of clinical osteoarthritis.
- Osteoarthritis of the knee: effects on gait, strength, and flexibility.
- Herbal therapy for treating osteoarthritis
- Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling‐induced ERK activation and c‐fos gene expression in cardiac myocytes.
- High glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells.
- The effects of therapeutic touch on patients with osteoarthritis of the knee.
- Hepatocyte growth factor facilitates cartilage repair. Full thickness articular cartilage defect studied in rabbit knees.
- Glucose modulates growth of gingival fibroblasts and periodontal ligament cells: correlation with expression of basic fibroblast growth factor.
- Shrinkage-induced Protein Tyrosine Phosphorylation in Chinese Hamster Ovary Cells*
- Further Comparative Analyses of Pretest-Posttest Research Designs
- Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis.
- Osteoarthritis of the knee and associated factors of age and obesity: effects on gait.
- Osteoarthritis of the knee.
- Stress signaling in yeast
- Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4.
- Sequential effects of high glucose on mesangial cell transforming growth factor-beta 1 and fibronectin synthesis.
- A TREATMENT FOR SUBLUXATION OF THE TEMPOROMANDIBULAR JOINT
Cited by
- Dextrose Prolotherapy: A Narrative Review of Basic Science, Clinical Research, and Best Treatment Recommendations.
- Treatment of painful advanced internal lumbar disc derangement with intradiscal injection of hypertonic dextrose.
- Prolotherapy (Proliferation Therapy) in the Treatment of TMD
- Fluoroscopically guided cervical prolotherapy for instability with blinded pre and post radiographic reading.
- Sclerotherapy of Baker's cyst with imaging confirmation of resolution.
- "Prolotherapy in Temperomandibular Disorders: an Overview"
- Prospective Evaluation of Intra-Articular Dextrose Prolotherapy for Treatment of Osteoarthritis in Dogs.
- PURLs: Prolotherapy: a nontraditional approach to knee osteoarthritis.
- Investigation the efficacy of intra-articular prolotherapy with erythropoietin and dextrose and intra-articular pulsed radiofrequency on pain level reduction and range of motion improvement in primary osteoarthritis of knee
- Prolotherapy for Arthritis- A Review
- Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial
- Prolotherapy: An Effective Adjunctive Therapy for Knee Osteoarthritis
- Dextrose Prolotherapy for Knee Osteoarthritis: A Randomized Controlled Trial
- Evidence based knee injections for the management of arthritis
- The Biology of Prolotherapy and Its Application in Clinical Cervical Spine Instability and Chronic Neck Pain: A Retrospective Study
- Regenerative medicine in the field of pain medicine: Prolotherapy, platelet-rich plasma therapy, and stem cell therapy—Theory and evidence
- Treatment of cervicothoracic pain and cervicogenic headaches with regenerative injection therapy
- Regenerative Injection of Elite Athletes with Career-Altering Chronic Groin Pain Who Fail Conservative Treatment: A Consecutive Case Series
- The verdict favors nonsteroidal antiinflammatory drugs for treatment of osteoarthritis and a plea for more evidence on other treatments.
- A Systematic Review of Prolotherapy for Chronic Musculoskeletal Pain
Related papers
- The Effect of Prolotherapy for Osteoarthritis of the Knee
- Short-term placebo response in trials of patients with symptomatic osteoarthritis: differences between hip and knee.
- Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study
- Evaluating the effects of ginger extract on knee pain, stiffness and difficulty in patients with knee osteoarthritis
- The association between radiographic knee osteoarthritis and knee symptoms, function and quality of life 10–15 years after anterior cruciate ligament reconstruction
- Prolotherapy for knee osteoarthritis
- Effects of Psidium guajava Linn. leaf extract in Japanese subjects with knee pain: a randomized, double-blind, placebo-controlled, parallel pilot study
- Periarticular dextrose prolotherapy instead of intra-articular injection for pain and functional improvement in knee osteoarthritis
- A within-person, between-knee comparison of intra-articular platelet-rich plasma versus placebo injection in knees osteoarthritis: a randomized, double-blind comparison
- Short-Term Effect of a New Oral Sodium Hyaluronate Formulation on Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial